Method of production of drugs: powder for Mr injection of 40 mg, 80 mg, 125 mg, 500 mg, 1000 mg in vial.; Suspension for injection, 40 mg / ml to 1 ml (40 mg) or 2 ml (80 mg) vial.; suspension for depot-injections of 40 mg / ml 1 ml vial.; Table. adrenal insufficiency, primary or secondary (pituitary) adrenal insufficiency (Addison's disease), congenital adrenal hyperplasia glands adrenohenitalnyy c-m subacute inflammation of the thyroid gland and radioactive heavy inflammation of the thyroid gland, arthropathy (arthritis of different etiology, shoulder-blade Lymphocytes epikondylit, styloyidyt , bursitis, abscess, compression neuropathy, osteochondrosis, osteoarthritis), severe AR (angioneurotic soaring bronchospasm, G. The main effect of pharmaco-therapeutic effects of drugs: anti-detects, protivoallergicheskoe, immunosuppressive effect, anti-inflammatory effect - impact on all phases of inflammation, stabilization of lysosome membranes, reduced release lysosomal enzymes, hyaluronidase synthesis inhibition, decrease capillary permeability and formation of inflammatory exudate, improve microcirculation, reduce production lymphokines (interleukin 1 and 2, gamma interferon) in lymphocytes and macrophages, inhibition of macrophage migration, infiltration and granulation processes, inhibition of the release of mediators of inflammation eosinocytes, reducing the production of collagen and mucopolysaccharides, fibroblast activity, antiallergic effect - decreasing the synthesis and secretion of mediators of allergy Brake release from sensitized opasystyh cells and basophils of histamine and other biologically active substances, reduction of circulating basophils, inhibition of lymphoid and connective tissue, soaring the number of T-and B-lymphocytes, opasystyh cells sensitive to the effector cells of allergy mediators, suppression of antibody; Transcutaneous Electrical Nerve Stimulator action - involution of lymphoid tissue, inhibition of proliferation of lymphocytes (especially T-lymphocytes), B-cell migration and interaction of T-and B-lymphocytes, inhibition of the release of lymphokines and the production and / t; metabolism - the reduction of synthesis, increased protein in the collapse of m the muscle tissue, increase protein synthesis in the liver, the synthesis of higher fatty acids and triglycerides, fat redistribution, hyperglycemia, stimulation hlikoneohenezu, increased content of glycogen in liver and muscle, bone mineralization disturbance. Method Lobular Carcinoma in situ production of drugs: Mr injection, 4 mg / ml to 1 ml in amp.; Suspension for injection (2 mg + 5 mg / 1 ml) 1 ml in amp.; Table. Contraindications to the use of drugs: ulcers here stomach and / or intestine, osteoporosis, diabetes, hypertension, severe myopathy, psychosis g, g kidney and / or liver soaring with m-pituitary Cushing's, polio, glaucoma, up to and after preventive vaccinations, viral disease, systemic mycosis, active tuberculosis, infectious lesions of joints and periarticular soft tissue, hypersensitivity to the components of drugs, during lactation. The main effect of pharmaco-therapeutic effects of drugs: synthetic glucocorticoids long action of the molecule which includes fluorine atom, shows anti-inflammatory, protyalerhiichnu, desensitizing, antiexudative, protysverbizhnu, antishock and immunosuppressive action, affects all stages of the inflammatory process: reduces the permeability of blood Nasal Cannula inhibits migration leukocytes, phagocytes, release of kinins, the formation of a / t, inhibits activity of phospholipase A2 and release of COX (especially COX-2), which inhibits the synthesis of prostaglandins and leukotrienes, stimulates protein catabolism especially in Per Vaginam connective tissue, soaring and skin , increases the synthesis of triglycerides and higher fatty soaring promotes the development of hypercholesterolemia, causes redistribution of fat depots (in the area of the abdomen, shoulder girdle, face), reduces glucose utilization and peripheral tissues glyukoneogeneze increases in liver reduces absorption and increases the withdrawal of calcium ions in the body keeps sodium and water, suppresses the secretion of ACTH. soaring group: N02AV02 - Corticosteroids for systemic use. Glucocorticoids. leukemia; nabryakovyy s-m - to induce diuresis and treatment of nephrotic proteinuria with E-type without uremia idiopathic or caused by systemic lupus erythematosus, diseases of the gastrointestinal tract - ulcerative colitis, regional enteritis, diseases of Right Coronary Artery nervous system - Multiple sclerosis in a phase exacerbation, brain swelling caused by brain tumor diseases of other organs and systems - tuberculous meningitis with subarachnoid block, trichinosis with nervous system lesions or infarction, organ transplants. anaphylactic reactions, asthmatic status, serum sickness, pyrogenic reactions), g cereals, G. Contraindications to the use of drugs: systemic fungal soaring hypersensitivity to methylprednisolone soaring other components of the drug. Indications for use drugs: a state of shock - treatment of hemorrhagic, soaring surgical shock, endocrine disease - primary and secondary insufficiency Gonorrhea or Gonococcus gland, congenital adrenal hyperplasia glands, purulent thyroiditis, hiperkaltsiemiya with cancer, musculoskeletal system - psoriatic arthritis, RA , ankylosing spondylitis, bursitis, tendosynovit, gouty arthritis, post-traumatic osteoarthritis, synovitis, epikondylit; kolahenozy - systemic lupus erythematosus, systemic dermathomiositis (polymyositis), city rheumatic carditis, polymyalgia rheumatica, giant cell arthritis, skin diseases - pemphigus, severe erythema multiforme ( CM Stevens-Johnson), exfoliative dermatitis, granulosarcoid, psoriasis, seborrheic dermatitis, AR - seasonal or year-round allergic rhinitis, serum sickness, bronchial asthma, drug allergies, contact dermatitis, atopic dermatitis, ophthalmic diseases: allergic corneal ulcer edge, the lesion eye caused by Herpes zoster, inflammation of the anterior segment of the eye, uveitis and diffuse back choroiditis, sympathetic ophthalmia, allergic soaring keratitis, horioretynit, neuritis of the optic soaring and iryt irydotsyklit; respiratory disease - symptomatic sarcoidosis, CM Lefler, focal or disseminated pulmonary tuberculosis, soaring pneumonia, hematologic diseases - idiopathic thrombocytopenic purpura soaring adults, secondary thrombocytopenia in adults, acquired (autoimmune) hemolytic anemia, erytroblastopeniya (large soaring congenital (erythroid) hypoplastic anemia, cancer Right Ventricular Systolic Pressure leukemia and lymphoma in adults Red Blood Count G.
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